It’s not about what works for you. It’s about what works for your users.
If a very complicated set-up with seven brand-new libraries and frameworks and a bunch of other tools satisfies you completely as a web developer but slows your sites down to a crawl for your users, you’re doing it wrong.
If serving your users’ needs requires you to use other tools than the ones you’d really like to use, you should set your personal preferences aside, even though it may make you feel less good. You have a job to do.
But it’s worth remembering this caveat too.