An excellent statement of intent from Mark. You can either read this now and start creating websites the right way, or you can scrabble to catch up further down the line; I recommend reading this now.
Embrace the fluidity of the web. Design layouts and systems that can cope to whatever environment they may find themselves in. But the only way we can do any of this is to shed ways of thinking that have been shackles around our necks. They’re holding us back.
Start designing from the content out, rather than the canvas in.